Frequently Asked Questions

How does conditional approval differ from traditional/formal approval?
The FDA grants drug approvals following successful demonstration of efficacy, safety and manufacturing protocols. A conditional approval is granted for only certain types of treatments for serious or life-threatening conditions where demonstrating effectiveness requires complex or difficult studies.

Once safety and manufacturing protocols have been proven, the FDA will consider an approval when there is a reasonable expectation of effectiveness for use. The conditional approval is valid for one year, after which it must be renewed annually (for up to four additional years) by demonstrating progress toward full approval.

Can I transition my dog from the previous bottle of KBroVet tablets directly to the new KBroVet® tablets without a washout or transition period?

Yes.

Are there any special diet implications to keep in mind when my dog is prescribed KBroVet®?

Dogs receiving KBr should be carefully monitored when changing diets, administering chloride-containing IV fluids, and administering concurrent medications. Careful monitoring is important in dogs that have a condition that may cause difficulty maintaining electrolyte balance.

If my dog’s seizure frequency increases, can I increase the dose of KBroVet®?

Please consult your veterinarian if seizure frequency increases. The total recommended daily dosage range for oral administration is 25–68 mg/kg (11–31 mg/lb) of body weight. The dosage of KBroVet should be adjusted based on monitoring of clinical response of the individual dog.

Are KBroVet® tablets flavored?

Yes, the tablets contain a proprietary flavoring to increase acceptance by dogs.

Are the new KBroVet® tablets scored? Can I split KBroVet® tablets?
Tablets are not scored, nor can tablet uniformity across the tablet be guaranteed. It is not recommended that the tablets be split.
How should KBroVet® tablets be stored?

Store at controlled room temperature 20–25°C (68–77°F). Keep out of reach of children and animals. Additionally, clients should be advised to keep KBroVet in a secured location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.

What are the differences between KBroVet® (potassium bromide chewable tablets) and the former KBroVet tablets?

The two products are labeled differently due the FDA’s approval of KBroVet. Please see the full product label and package insert for details. Additionally, the tablets are no longer scored, nor contain cyanocobalamin (vitamin B-12). All other ingredients remain the same.

How do KBroVet® tablets work to control seizures?
The active ingredient, potassium bromide, is thought to exert its antiepileptic activity by passing through neuronal chloride ion channels, thereby hyperpolarizing neuronal membranes. With the neuronal membranes more negatively charged, this decreases the action potential across the synapse, thus raising the seizure threshold and stabilizing neurons against excitatory input from epileptic foci.
What are side effects of KBroVet®?

The most commonly reported side effects were increased appetite and thirst, increased urination, weight gain, sedation, and ataxia. For full prescribing information see the package insert by clicking here.

Are there contraindications for other medications in which KBroVet® should not be used?

KBroVet should not be used in animals with a history of hypersensitivity to bromide. Please see full product label and package insert for all labeled contraindications, warning and precautions.

Talk to your veterinarian about KBroVet®

Talk to your veterinarian about KBroVet®

Is the cloud of idiopathic epilepsy casting a shadow on day-to-day life with your dog? Be prepared to discuss treatment options and why KBroVet might be the right choice for your dog.